Midbrain SERT in degenerative parkinsonisms: A 123I‐FP‐CIT SPECT study
Identifieur interne : 000645 ( Main/Exploration ); précédent : 000644; suivant : 000646Midbrain SERT in degenerative parkinsonisms: A 123I‐FP‐CIT SPECT study
Auteurs : Francesco Roselli [Italie, Allemagne] ; Nicola M. Pisciotta [Italie] ; Michele Pennelli [Italie] ; Maria S. Aniello [Italie] ; Angelo Gigante [Italie] ; Maria F. De Caro [Italie] ; Ermanno Ferrannini [Italie] ; Bruno Tartaglione [Italie] ; Artor Niccoli-Asabella [Italie] ; Giovanni Defazio [Italie] ; Paolo Livrea [Italie] ; Giuseppe Rubini [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
English descriptors
Abstract
SPECT imaging is widely used for the differential diagnosis of degenerative parkinsonisms by exploiting the high affinitiy of the radiotracer 123I‐FP‐CIT for the dopamine transporter. Reduced levels of DAT are found in Parkinson Disease (PD), Dementia with Lewy Bodies (DLB), and Progressive Supranuclear Palsy (PSP) compared to in Essential Tremor (ET) and Healthy Controls (HC). However, the extent of the neurodegenerative process may extend beyond nigrostriatal system. We have exploited the affinity of the same radiotracer 123I‐FP‐CIT for the serotonin transporter to investigate SERT levels in the midbrain of patients with PD, DLB, PSP, and ET compared to HC. Using MRI images as anatomical templates for midbrain uptake quantification, we found a mild decrease in SERT levels in PD compared to ET and HC, with marked inter‐individual variability; on the other side, PSP and DLB patients displayed markedly reduced to undetectable levels of SERT, respectively. These findings show that the neurodegenerative process affects serotoninergic neurons in parkinsonisms, with much more severe involvement in DLB than in PD patients, despite the comparable loss of striatal DAT. SERT‐dependent 123I‐FP‐CIT uptake may allow a more comprehensive assessment of neurochemical disturbances in degenerative parkinsonisms and may have a value for differential diagnosis. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23179
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-09-15">2010-09-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1853">1853</biblScope><biblScope unit="page" to="1859">1859</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C4617C03643F1E1B2F884C56D77C9C1681700D24</idno><idno type="DOI">10.1002/mds.23179</idno><idno type="ArticleID">MDS23179</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>123I‐FP‐CIT</term><term>SPECT</term><term>dementia with Lewy bodies</term><term>parkinsonism</term><term>serotonin transporter</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">SPECT imaging is widely used for the differential diagnosis of degenerative parkinsonisms by exploiting the high affinitiy of the radiotracer 123I‐FP‐CIT for the dopamine transporter. Reduced levels of DAT are found in Parkinson Disease (PD), Dementia with Lewy Bodies (DLB), and Progressive Supranuclear Palsy (PSP) compared to in Essential Tremor (ET) and Healthy Controls (HC). However, the extent of the neurodegenerative process may extend beyond nigrostriatal system. We have exploited the affinity of the same radiotracer 123I‐FP‐CIT for the serotonin transporter to investigate SERT levels in the midbrain of patients with PD, DLB, PSP, and ET compared to HC. Using MRI images as anatomical templates for midbrain uptake quantification, we found a mild decrease in SERT levels in PD compared to ET and HC, with marked inter‐individual variability; on the other side, PSP and DLB patients displayed markedly reduced to undetectable levels of SERT, respectively. These findings show that the neurodegenerative process affects serotoninergic neurons in parkinsonisms, with much more severe involvement in DLB than in PD patients, despite the comparable loss of striatal DAT. SERT‐dependent 123I‐FP‐CIT uptake may allow a more comprehensive assessment of neurochemical disturbances in degenerative parkinsonisms and may have a value for differential diagnosis. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Italie</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Roselli, Francesco" sort="Roselli, Francesco" uniqKey="Roselli F" first="Francesco" last="Roselli">Francesco Roselli</name></noRegion><name sortKey="Aniello, Maria S" sort="Aniello, Maria S" uniqKey="Aniello M" first="Maria S." last="Aniello">Maria S. Aniello</name><name sortKey="De Caro, Maria F" sort="De Caro, Maria F" uniqKey="De Caro M" first="Maria F." last="De Caro">Maria F. De Caro</name><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name><name sortKey="Ferrannini, Ermanno" sort="Ferrannini, Ermanno" uniqKey="Ferrannini E" first="Ermanno" last="Ferrannini">Ermanno Ferrannini</name><name sortKey="Gigante, Angelo" sort="Gigante, Angelo" uniqKey="Gigante A" first="Angelo" last="Gigante">Angelo Gigante</name><name sortKey="Livrea, Paolo" sort="Livrea, Paolo" uniqKey="Livrea P" first="Paolo" last="Livrea">Paolo Livrea</name><name sortKey="Niccoli Sabella, Artor" sort="Niccoli Sabella, Artor" uniqKey="Niccoli Sabella A" first="Artor" last="Niccoli-Asabella">Artor Niccoli-Asabella</name><name sortKey="Pennelli, Michele" sort="Pennelli, Michele" uniqKey="Pennelli M" first="Michele" last="Pennelli">Michele Pennelli</name><name sortKey="Pisciotta, Nicola M" sort="Pisciotta, Nicola M" uniqKey="Pisciotta N" first="Nicola M." last="Pisciotta">Nicola M. Pisciotta</name><name sortKey="Rubini, Giuseppe" sort="Rubini, Giuseppe" uniqKey="Rubini G" first="Giuseppe" last="Rubini">Giuseppe Rubini</name><name sortKey="Tartaglione, Bruno" sort="Tartaglione, Bruno" uniqKey="Tartaglione B" first="Bruno" last="Tartaglione">Bruno Tartaglione</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Roselli, Francesco" sort="Roselli, Francesco" uniqKey="Roselli F" first="Francesco" last="Roselli">Francesco Roselli</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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